The first international break of the 2021/22 season is in the history books, meaning it's back to Premier League action for all 20 top-flight teams.
The weekend's drama should see Cristiano Ronaldo appear for Manchester United for the first time in 12 years, following his dramatic return from Juventus, while there should also be a host of other debuts up and down the country after a hectic end to the transfer window.
Here's your full weekend preview of where to watch every game, as well as those all important predictions.
Saturday
Crystal Palace vs Tottenham
When is kick off? Saturday 11 September, 12:30 (BST)
Where is the match being played? Selhurst Park
TV channel/live stream? BT Sport (UK), fuboTV ( US)
Highlights? Sky Sports YouTube Channel (UK - 5.15pm), Match of the Day (BBC - UK)
Referee?Jonathan Moss
VAR?Jarred Gillett
Crystal Palace put in a promising performance last time out, scooping a point at West Ham thanks to a superb showing from two-goal Conor Gallagher.
They face a Spurs side who have won three out of three, are top of the table, and are yet to concede a goal.
Full match preview
Crystal Palace predicted lineup
Tottenham predicted lineup
Prediction: Crystal Palace 1-1 Tottenham
Arsenal vs Norwich
When is kick off? Saturday 11 September, 15:00 (BST)
Where is the match being played? Emirates Stadium
TV channel/live stream? Final Score (BBC - UK), Soccer Saturday (Sky Sports - UK), fuboTV (US)
Highlights? Sky Sports YouTube Channel (UK - 5.15pm), Match of the Day (BBC - UK)
Referee? Michael Oliver
VAR? Mike Dean
Not one person in the country, regardless of their allegiance, would have predicted Arsenal to be facing Norwich without a point to their name after three Premier League games - and having failed to score a single goal.
But that's where Mikel Arteta and his side are, though fortunately they now have the chance to get off the mark against a Norwich side also pointless and bottom of the table.
Full match preview
Arsenal predicted lineup
Norwich predicted lineup
Prediction: Arsenal 2-1 Norwich
Brentford vs Brighton
When is kick off? Saturday 11 September, 15:00 (BST)
Where is the match being played? Brentford Community Stadium
TV channel/live stream? Final Score (BBC - UK), Soccer Saturday (Sky Sports - UK), Peacock Premium (US)
Highlights? Sky Sports YouTube Channel (UK - 5.15pm), Match of the Day (BBC - UK)
Referee? Graham Scott
VAR? Lee Mason
Two of the Premier League's most aesthetically pleasing sides meet on Saturday, when Brentford host Brighton in west London.
Both have enjoyed decent starts to the season; the Bees are unbeaten in their first three following promotion while the Seagulls have picked up six points from a possible nine.
Full match preview
Prediction: Brentford 1-2 Brighton
Leicester vs Man City
When is kick off? Saturday 11 September, 15:00 (BST)
Where is the match being played? King Power Stadium
TV channel/live stream? Final Score (BBC - UK), Soccer Saturday (Sky Sports - UK), Peacock Premium (US)
Highlights? Sky Sports YouTube Channel (UK - 5.15pm) Match of the Day (BBC - UK)
Who's the referee? Paul Tierney
Who's on VAR duty? Andre Marriner
Leicester's meetings with Manchester City are always eventful, and the outcome isn't always what you would expect it to be.
The Foxes ran riot in Manchester last year, winning 5-2 at the Etihad, but inevitably lost the reverse fixture at King Power Stadium. They did, however, win when it really mattered: in the FA Cup final and Community Shield.
It should be another good game here.
Full match preview
Leicester predicted lineup
Man City predicted lineup
Prediction: Leicester 2-2 Manchester City
Man Utd vs Newcastle
When is kick off? Saturday 11 September, 15:00 (BST)
Where is the match being played? Old Trafford
TV channel/live stream? Final Score (BBC - UK), Soccer Saturday (Sky Sports- UK), fuboTV (US)
Highlights? Sky Sports YouTube Channel (UK - 5.15pm), Match of the Day (BBC - UK)
Referee? Anthony Taylor
VAR? Craig Pawson
There's only one real talking point in this one; will Cristiano Ronaldo be handed a first (or second first?) Man Utd start by Ole Gunnar Solskjaer?
If he is, watch out Newcastle - the Portuguese has great scoring record against the Magpies and will be desperate to steal the show.
Full match preview
Man Utd predicted lineup
Newcastle predicted lineup
Prediction: Man Utd 3-0 Newcastle
Southampton vs West Ham
When is kick off? Saturday 11 September, 15:00 (BST)
Where is the match being played? St Mary's Stadium
TV channel/live stream? Final Score (BBC - UK), Soccer Saturday (Sky Sports- UK), Peacock Premium (US)
Highlights? Sky Sports YouTube Channel (UK - 5.15pm) Match of the Day (BBC - UK)
Referee? David Coote
VAR? Martin Atkinson
West Ham travel to Southampton on Saturday afternoon looking to make it four Premier League games unbeaten to start the season.
The hosts, meanwhile, have two points to their name, drawing against Manchester United and Newcastle - the latter salvaged by a 96th-minute James Ward-Prowse penalty before the international break.
Full match preview
Southampton predicted lineup
West Ham predicted lineup
Prediction: Southampton 1-3 West Ham
Watford vs Wolves
When is kick off? Saturday 11 September, 15:00 (BST)
Where is the match being played? Vicarage Road
TV channel/live stream? Final Score (BBC - UK), Soccer Saturday (Sky Sports - UK), Peacock Premium (US)
Highlights? Sky Sports YouTube Channel (UK - 5.15pm) Match of the Day (BBC - UK)
Referee? Peter Bankes
VAR? Simon Hooper
Watford's return to Premier League life got off to a dream start, but victory on the opening day against Aston Villa has been tempered by two consecutive defeats.
Their opponents this weekend are a winless Wolves, who have tasted defeat in each of their three league games this season. Something has got to give in Hertfordshire...or has it?
Full match preview
Watford predicted lineup
Wolves predicted lineup
Prediction: Watford 2-2 Wolves
Chelsea vs Aston Villa
When is kick off? Saturday 11 September, 17:30 (BST)
Where is the match being played? Stamford Bridge
TV channel/live stream? Sky Sports (UK), fuboTV (US)
Highlights? Match of the Day (BBC - UK)
Referee? Stuart Attwell
VAR? Chris Kavanagh
Chelsea's 2021/22 campaign has started off strongly, winning the UEFA Super Cup against Villarreal while picking up seven points from a possible nine in the Premier League.
The Blues play host to Aston Villa at Stamford Bridge this weekend, who have put their opening day defeat at Watford behind them to claim four points from their last two. In Danny Ings, Villa have a real goal threat.
Full match preview
Chelsea predicted lineup
Aston Villa predicted lineup
Prediction: Chelsea 2-1 Aston Villa
Sunday
Leeds vs Liverpool
When is kick off? Sunday 12 September, 16:30 (BST)
Where is the match being played? Elland Road
TV channel/live stream? Sky Sports (UK), fuboTV (US)
Highlights? Match of the Day 2 (BBC - UK)
Referee? Craig Pawson
VAR? Darren England
In the most shocking turn of the weekend there is only one game to entertain the masses on Sunday afternoon, but what a game it could be as Leeds host Liverpool at Elland Road.
Marcelo Bielsa's side are always entertaining, expansive and electrifying to watch, and the same can be said for Jurgen Klopp's Liverpool when they are firing on all cylinders. Luckily for us, the Reds are in good form - so cue the most unexpected 0-0 draw...
Prediction: Leeds 0-0 Liverpool
Monday
Everton vs Burnley
When is kick off? Monday 13 September, 20:00 (BST)
Where is the match being played? Goodison Park
TV channel/live stream? Sky Sports (UK), fuboTV (US)
Referee? Andre Marriner
VAR? Kevin Friend
Gameweek four ends with an in-form Everton welcoming Burnley to Goodison Park for Monday night football.
Rafa Benitez's men have seven points and seven goals to their name after three impressive performances, but it has been the same old slow start for Sean Dyche's Clarets - they have just a solitary point in the bag so far.
The form book usually goes out of the window somewhere, though, and it could be here.
Prediction: Everton 0-1 Burnley
Source : 90min